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| Registros recuperados: 163 | |
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| Cetik,Songul; Ayhanci,Adnan; Sahinturk,Varol. |
| Possible protective effects of carvacrol (Car) against cyclophosphamide (CP)-induced cardiotoxicity was examined in this study. Experimental groups of the rats were randomly divided into 13 groups,each including seven animals: Group 1 (control) treated with saline; groups 2, 3, and 4 treated with 50, 100, or 150 mg/kg of CP, respectively; group 5 treated with 0.5 mL olive oil; groups 6 and 7 treated with 5.0 and 10 mg/kg of Car, respectively; groups 8, 9, or 10 treated with respective CP plus 5.0 mg/kg of Car; and groups 11, 12, or 13 treated with respective CP plus 10 mg/kg of Car. Serum alanine transaminase (ALT),aspartat transaminase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA),creatine kinase-MB (CK-MB), total oxidant state (TOS),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cyclophosphamide; Oxidative stress; Cardiotoxicity; Carvacrol; Antioxidant; Rat. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400569 |
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| Özevren,Hüseyin; Deveci,Engin. |
| Head trauma affects the optic nerve visual function and visual acuity. As a result of head trauma occurring in the retina of the various biochemical, histological and immunohistochemical effects were investigated. The protective effect of Ganoderma lucidum was evaluated on the damage to the retina of the rats. Sprague-Dawley rats were subjected to traumatic brain injury with a weight-drop device using 300 g-1 m weight-height impact. Thirty rats were divided into three groups as group 1 control, 2 group trauma, 3 group trauma+Gonoderma lucidum (20 mL/kg per day via gastric gavage) Ganoderma lucidum was administered for 7 days after trauma.All rats were decapitated 5 days after the induction of trauma, and the protective effects of Ganoderma lucidum in... |
| Tipo: Journal article |
Palavras-chave: Head trauma; Retina; Ganoderma lucidum; Rat. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300040 |
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| Can,Senanur; Canbek,Mediha. |
| Abstract Possible protective effects of geraniol, known as antioxidant properties, were analyzed biochemically and histologically on experimental long-term renal ischemia/reperfusion I/R injury in rats. This study used 3-4 months old male Wistar albino rats and were divided into 4 groups (n = 7) by random selection: Group I (Sham Group), Group II (I/R+SF), Group III (I/R+50 mg/kg geraniol), and Group IV (I/R+100 mg/kg geraniol). A right nephrectomy was performed in all groups under anesthesia. Groups I and II were inoculated with SF (1 ml/kg) and Groups III and IV were inoculated with 50 mg/kg and 100 mg/kg of geraniol, injected intraperitoneally. For Groups II, III, and IV, I/R durations were determined to be 60 mins ischemia and 24 hours reperfusion. At... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ischemia; Reperfusion; Geraniol; Antioxidant; Protective effects; Rat. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100314 |
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| Zhao,Liping; Yan,Wenhui; Xiang,Heng; Wang,Xiaoyang; Qiao,Haixuan. |
| The mechanisms of exercise-induced fatigue have not been investigated using proteomic techniques, an approach that could improve our understanding and generate novel information regarding the effects of exercise. In this study, the proteom alterations of rat skeletal muscle were investigated during exercise-induced fatigue. The proteins were extracted from the skeletal muscle of SD rat thigh, and then analyzed by two-dimensional electrophoresis and PDQuest software. Compared to control samples, 10 significantly altered proteins were found in exercise samples, two of them were upregulated and eight of them were downregulated. These proteins were identified by MALDI TOF-MS. The two upregulated proteins were identified as MLC1 and myosin L2 (DTNB) regulatory... |
| Tipo: Journal article |
Palavras-chave: Proteomics; Exercise-induced fatigue; Skeletal muscle; Rat. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100010 |
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| Ferreira-Medeiros,Mildred; Correa-Gillieron,Elenice. |
| Lectins are proteins with binding sites that recognize a specific sequence of sugar moieties in complex glycoconjugates. In the present study the tomato lectin Lycopersicon esculentum (LEL) (a selective microglial and endothelial marker) has been reported to recognize specific residues of N-acetylglucosamine (GlyNAc) and poly-N-acetyllactosamine. In the pineal gland the biotinylated LEL was used to investigate the appearance of these sugar residues in the structures of the rats during their development and adult life. Our results showed that the binding of LEL occurred exclusively in the material adherents on surface of the endothelia of the vessels in the peripheral and central regions of the gland. An exception can be cited to rats in first postnatal... |
| Tipo: Journal article |
Palavras-chave: Pineal; Rat; Lectins; Development; Rosettes; Endothelia. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000400008 |
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| Minamoto,V.B.; Bunho,S.R.; Salvini,T.F.. |
| In the present study we evaluated the morphological aspect and changes in the area and incidence of muscle fiber types of long-term regenerated rat tibialis anterior (TA) muscle previously submitted to periodic contusions. Animals received eight consecutive traumas: one trauma per week, for eight weeks, and were evaluated one (N = 8) and four (N = 9) months after the last contusion. Serial cross-sections were evaluated by toluidine blue staining, acid phosphatase and myosin ATPase reactions. The weight of injured muscles was decreased compared to the contralateral intact one (one month: 0.77 ± 0.15 vs 0.91 ± 0.09 g, P = 0.03; four months: 0.79 ± 0.14 vs 1.02 ± 0.07 g, P = 0.0007, respectively) and showed abundant presence of split fibers and fibers with... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Skeletal muscle; Periodic contusion; Long-term regeneration; Rat. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100012 |
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| Romanini,M. C; Paz,D. A.; Rodríguez,N; Rolando,A. N.; Mugnaini,M. T.; Soñez,C. A.; Bozzo,A; Marioli,J. M.; Pastorino,I. C; Gauna,H. F.. |
| The chronic stress induces functional adaptations in the hypothalamo-pituitary- adrenocortical (HPA) and in the sympathetic-medullary-adrenal axis (SAM). Both axis are considered vital regulators of the homeostasis in vertebrates (Seyle, 1936; Ostrandrer et al, 2006. On the other hand, the placenta provides highly specialized functions during gestation that are critical for the normal development of the embryo/fetus (Soares et al., 1991). We hypothesized that the chronic immobilization (IMO) stress in pregnancy rats produces alterations in prolactin concentrations in placental tissue and also changes in the response of SAM axis. Chronic stress by IMO was applied on days 12, 17 and 21 of pregnancy rats. Relative concentrations and localization of placental... |
| Tipo: Journal article |
Palavras-chave: Chronic stress; Placental lactogen; Prolactin; Rat; SAM. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000100011 |
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| HAMAME,CARLOS M; DELANO,PAUL H; ROBLES,LUIS. |
| Relevance of a neutral cue for performance in a two-choice visuospatial detection task was examined. Nine rats were trained, 5 with short intertrial interval (ITI) and 4 with long ITI, to detect a target (lateral lights) presented after a neutral-cue (central light). The removal of the neutral-cue decreased accuracy and increased response latencies and omissions. These results demonstrate that a neutral-cue, preceding the target, is relevant for the performance, suggesting that rats are highly expectant during the neutral-cue and reallocate attentional resources during ITI. Furthermore, latencies were higher, omissions were lower and the fall of accuracy was greater for rats with long than with short ITI, which could indicate that the neutral-cue was more... |
| Tipo: Journal article |
Palavras-chave: Attention; Expectancy; Neutral cue; Attentional task; Rat. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000200008 |
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| Alves-Neto,O.; Tavares,P.; Rocco,P.R.M.; Zin,W.A.. |
| Ketamine is believed to reduce airway and pulmonary tissue resistance. The aim of the present study was to determine the effects of ketamine on the resistive, elastic and viscoelastic/inhomogeneous mechanical properties of the respiratory system, lungs and chest wall, and to relate the mechanical data to findings from histological lung analysis in normal animals. Fifteen adult male Wistar rats were assigned randomly to two groups: control (N = 7) and ketamine (N = 8). All animals were sedated (diazepam, 5 mg, ip) and anesthetized with pentobarbital sodium (20 mg/kg, ip) or ketamine (30 mg/kg, ip). The rats were paralyzed and ventilated mechanically. Ketamine increased lung viscoelastic/inhomogeneous pressure (26%) compared to the control group. Dynamic and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ketamine; Elastance; Lung tissue; Resistive pressure; Viscoelasticity; Rat. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000900016 |
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| Fabris,G.; Anselmo-Franci,J.A.; Branco,L.G.S.. |
| Hypoxia elicits hyperventilation and hypothermia, but the mechanisms involved are not well understood. The nitric oxide (NO) pathway is involved in hypoxia-induced hypothermia and hyperventilation, and works as a neuromodulator in the central nervous system, including the locus coeruleus (LC), which is a noradrenergic nucleus in the pons. The LC plays a role in a number of stress-induced responses, but its participation in the control of breathing and thermoregulation is unclear. Thus, in the present study, we tested the hypothesis that LC plays a role in the hypoxia-induced hypothermia and hyperventilation, and that NO is involved in these responses. Electrolytic lesions were performed bilaterally within the LC in awake unrestrained adult male Wistar rats... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nitric oxide; Locus coeruleus; Hypoxia; Ventilation; Body temperature; Rat. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100009 |
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| Bicalho,K.A.; Araújo,F.T.M.; Rocha,R.S.; Carvalho,O.S.. |
| The sanitary conditions of 13 animal houses in nine public institutions in Minas Gerais, and the presence of endo and ectoparasites of mice and rats colonies kept in these facilities were evaluated. Data about barriers to prevent the transmission of diseases and a program of sanitary monitoring were obtained through a questionnaire and local visit. Parasitological methods were performed for diagnosing mite, lice, helminthes, and protozoa parasites in 344 mice and 111 rats. Data have shown that the majority of the animal houses had neither proper physical environment nor protection barriers to prevent the transmission of infections. Parasitological results have shown that only one animal house (7.7%) had parasite free animals, whereas the others have... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mice; Rat; Animal house; Parasite; Sanitary barrier. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000600020 |
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| Zhu,Lei; Wang,Jian Lin. |
| Fifty male and fifty female Spargue-Dawley rats were randomly chosen and used to study the sexual dimorphisms of stomachic histological structures. The rat stomach consisted of the nonglandular part and the glandular part. The gender differences of the nonglandular part existed in the thicknesses of the stratified squamous epithelium and the longitudinal muscle. These findings revealed that the male rat stomach may storage more foods than the female. The gastric glands occupied all the lamina propria in the glandular part. The thicknesses of the gastric glands of the female and male rat were 525.0 ± 95.9 µm and 472.0 ± 158.7 µm respectively, and the difference was very significant (p<0.01). The gastric glands could be divided to two layers in the HE... |
| Tipo: Journal article |
Palavras-chave: Rat; Stomach; Gastric glands; Nucleus-glandular index. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400046 |
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| Andrade,Filipe Moreira de; Judice,Luiz Felippe; Cisne,Rafael; Félix,Bruno; Mourad,Omar Moté Abou; Cardoso,Gilberto Perez; Babinski,Marcio Antonio. |
| The extracellular matrix is a key element in the tracheal morphology and physiology, both in normal and pathological states, yet little is known regarding its composition and organization. Herein we carried out a detailed study of the morphological organization and volumetric density of elastic system fibers in the trachea of Wistar rats. Six Wistar rats at the age of 45 days were used. The trachea was excised following anesthesia with Thiopental and perfusion through the left ventricle with buffered saline followed by formalin solution. Samples were fixed in formaline, embedded in paraffin, and histologically processed. The elastic system fibers were evaluated at light microscopy by using Weigert's resorcin-fuchsin technique after oxidation with oxone.... |
| Tipo: Journal article |
Palavras-chave: Rat; Trachea; Morphology; Elastic fibers; Quantitative evaluation. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100002 |
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| Registros recuperados: 163 | |
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